12-oxo-鹅去氧胆酸(12-oxo-CDCA)是从胆酸出发合成鹅去氧胆酸(CDCA)重要的中间体,鹅去氧胆酸(CDCA)是合成熊去氧胆酸的重要前体.鹅去氧胆酸(CDCA)和熊去氧胆酸(UDCA)在动物体内对胆固醇的降解具有十分重要的作用.但是,与熊去氧胆酸相比,鹅去氧胆酸在使用过程中的使用量较大,而且使用过程中的毒副作用也比较大...
12 alpha-Hydroxysteroid dehydrogenase (12 alpha-HSDH) has the potential to convert cheap and readily available cholic acid (CA) to 12-oxochenodeoxycholic acid (12-oxo-CDCA), a key precursor for chemoenzymatic synthesis of the therapeutic bile acid ursodeoxycholic acid (UDCA). In this work, a ...
12-ketochenodeoxycholic acid 5β-cholanoic acid-3α,7α-diol-12-one 12-Ketochenodeoxycholic Acid (12-Oxochenodeoxycholic Acid / 3,7-Dihydroxy-12-Oxocholanoic Acid) is a human metabolite and a derivative of chenodeoxycholic acid (CDCA/chenocholic acid), that bears an oxo-substituent at posit...
The oxysterols analyzed in this study were as follows: 4β-hydroxycholesterol (5-cholesten-3β,4β-diol; 4βOH), 5α-hydroxy-6-ketocholestanol (cholestan-3β,5α-diol-6-one; 5αOH,6oxo), 6-ketocholestanol (5α-cholestan-3β-ol-6-one; 6oxo), 7-ketocholesterol (5-cholesten-3β...