11C-CH3-Triflate甲基化法合成 11C-PK11195
C-PK 11195)在国内现有合成模块上进行自动化合成工艺,并建立 11 C-PK 11195的质量控制方法。方法利用国产 11 C-CH 3 I 合成模块生产的 11 C-CH 3 I与1-(2-氯苯基)-N-(1-甲基丙基)- 异喹啉-3-氨甲酰去甲基前体在TracerLab FX F-N 自动化合 成模块中进行甲基化反应,利用半制备型HPLC系统进行分离...
One of the first positron emission tomography (PET) radioligands for human studies of activated microglia translocator protein ((TSPO) overexpression) was PK11195, a lipid soluble isoquinoline carboxamide, which was enantiomerically labeled with carbon-11 ((R)-[N-methyl-C]PK11195) and it remains ...
Human biodistribution and ra- diation dosimetry of 11C-(R)-PK11195: the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging 2010; 37: 606-12.Hirvonen J, Roivainen A, Virta J, Helin S, Någren K, Rinne JO. Human biodistribution and radiation dosimetry of 11C-(...
Kojima, "Synthesis and Evaluation of 11C-PK 11195 for in Vivo Study of Peripheral-Type Benzodiazepine Recep- tors Using Positron Emission Tomography," Annals of Nuclear Medicine, Vol. 3, No. 2, 1989, pp. 63-71. doi:10.1007/BF03164587...
Hinz R, Jones M, Bloomfield PM, Boellaard R, Turkheimer FE, Tyrrell PJ. Reference tissue kinetics extraction from [11C]-(R)-PK11195 scans on the High Resolution Research Tomograph (HRRT) [abstract] Neuroimage. 2008; 41 (Suppl 2:T65....
Labelling of PK11195 analogues using [11C]carbon monoxidePK11195 analogues11C]Carbon monoxideNo abstract is available for this article.doi:10.1002/jlcr.25804401352O. RahmanT. KihlbergB. LångströmJohn Wiley & Sons, Ltd.Journal of Labelled Compounds & Radiopharmaceuticals...
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. Overexpression of the translocator protein, TSPO (18 kDa), formerly known as the peripheral benzodiazepine receptor, is a hallmark of activation of ...
Positron emission tomography (PET) with [(11)C]-(R)-PK11195 has already been used to visualize activated microglia cells in neurological diseases. However, [(11)C]-(R)-PK11195 may not possess the required sensitivity to visualize mild neuroinflammation. In this study, we evaluated the PET ...
IN VIVO IMAGING OF AMYLOID DEPOSITION AND NEUROINFLAMMATION IN MILD COGNITIVE IMPAIRMENT WITH 11C-PIB AND 11C-PK11195 PET.An of the article "In Vivo Imaging of Amyloid Deposition and Neuroinflammation in Mild Cognitive Impairment With 11C-PIB and 11C-PK11195 PET," is presented....