C-PK 11195)在国内现有合成模块上进行自动化合成工艺,并建立 11 C-PK 11195的质量控制方法。方法利用国产 11 C-CH 3 I 合成模块生产的 11 C-CH 3 I与1-(2-氯苯基)-N-(1-甲基丙基)- 异喹啉-3-氨甲酰去甲基前体在TracerLab FX F-N 自动化合 成模块中进行甲基化反应,利用半制备型HPLC系统进行分离...
11C-CH3-Triflate甲基化法合成 11C-PK11195
This study compares the reproducibility of the kinetic modeling for a PET brain study using IDIF and AIF for [11C]-PK11195, a marker of microglial activation.Methods A test-retest protocol was executed in 7 control subjects using [11C]-PK11195. The subjects were given two injections of the...
Furthermore, the DVR of [11C]-(R)-PK11195 in FM patients demonstrated decreased neuroinflammation in the medulla (p < 0.005), left superior temporal gyrus (p < 0.005), and left amygdala (p = 0.020) compared with healthy controls. Conclusions To the authors' knowledge, this report is the...
Hirvonen J, Roivainen A, Virta J, Helin S, Na˚gren K, et al. (2010) Human biodistribution and radiation dosimetry of 11C-(R)-PK11195; the prototypic PET ligand to image inflammation. Eur J Nucl Med Mol Imaging. 37: 606-612....
目的:采用[11C]PK11195作为PET/CT肝脏星形细胞特异性显像剂,研究肝脏早期纤维化不同阶段肝脏组织星形细胞对[11C]PK11195的摄取率,探讨[11C]PK11195在肝纤维化早期诊断的价值. 材料与方法:8周龄雄性Wistar大鼠,体重210-310g.采用硫代乙酰胺(thioacetamide,TAA)腹腔注射(每周三次)的方式对实验组... 查看全部>>关键...
Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Ann Nucl Med 1989;3:63-71.Hashimoto, K.; Inoue, O.; Suzuki, K.; Yamasaki, T.; Kojima, M. Synthesis and evaluation of 11C-PK 11195 for in vivo ...
Hinz R, Jones M, Bloomfield PM, Boellaard R, Turkheimer FE, Tyrrell PJ. Reference tissue kinetics extraction from [11C]-(R)-PK11195 scans on the High Resolution Research Tomograph (HRRT) [abstract] Neuroimage. 2008; 41 (Suppl 2:T65....
Biodistribution of the radionuclides 18F-FDG, 11C-methionine, 11C-PK11195, and 68Ga-citrate in domestic juvenile female pigs and morphological and molecula... Biodistribution of the radionuclides 18F-FDG, 11C-methionine, 11C-PK11195, and 68Ga-citrate in domestic juvenile female pigs and morpho- ...
IN VIVO IMAGING OF AMYLOID DEPOSITION AND NEUROINFLAMMATION IN MILD COGNITIVE IMPAIRMENT WITH 11C-PIB AND 11C-PK11195 PET.An abstract of the article "In Vivo Imaging of Amyloid Deposition and Neuroinflammation in Mild Cognitive Impairment With 11C-PIB and 11C-PK11195 PET," is presented....