Although test-retest reliability is critical to estimate a necessary sample size, this has not been established for 11C-ER176 PET. Because of the low specific and total binding, test-retest variability may be poor in LABs. In addition, one study indicated possible diurnal changes of TSPO ...
[11C]ER176 is a PET radioligand that images neuroinflammation via the 18-kDa translocator protein (TSPO), which is upregulated in activated microglia and has previously been a PET target in Alzheimer's disease research. Currently, the gold-standard method for quantifying ER176 PET is kinetic ...
[11C]ER176, specifically binding to TSPO, has been developed as the third generation of radioligand for PET imaging of TSPO, which showed the potential in better quantifying neuroinflammation than its predecessors. In the current study, we developed an automated radiosynthesis with an imp...
Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brainC-11-PBR28F-18-GE180TSPOF-18-GE180 is a third-generation PET tracer for qudoi:10.1007/s00259-019-04349-wPaolo Zanotti-Fregonara...
Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of inflammation, in the human brain and accurately quantify target density in homozygous low-affinity binders. Our laboratory sought ...
The sample corresponding to [11C]ER176 was collected into a vial that contained water (50 mL). The diluted fraction was passed through the Sep-Pak cartridge to remove the mobile phase solvent (35% MeCN: 65% 1 mM NH4OH aq) while [11C]ER176 was retained on the cartridge and rinsed with...