这种核素分子探针的设计精巧，它以二氢丁苯那嗪为基础结构，通过引入放射性同位素11C，赋予了其独特的示踪功能。11C是一种短寿命的放射性核素，具有合适的半衰期和衰变特性，使得它能够在生物体内进行精确的示踪研究。11C-DTBZ核素分子探针的应用广泛，特别是在神经科学研究领域，它能够精确定位并标记特定的生物分子，如多...
Results: The voxel-wise correlations showed a significant positive association between grip strength and the binding of 11C-DTBZ in various brain regions within subcortical and limbic areas (refer to Figure 1). To be specific, weaker grip strength was linked to reduced 11C-DTBZ binding, ...
C]DTBZ) was synthesized by reacting the 9-hydroxy precursor in DMSO with gas-phase [11C]methyl iodide on a column of alumina impregnated with KOH. The reaction was instantaneous at room temperature. This column was then connected to the inlet of a short column containing basic alumina. ...
18F-FPCIT探针的核心是其标记的氟-18（18F）核素，这是一种短寿命的放射性同位素，具有适宜的半衰期和能量，使其成为理想的示踪剂。通过与特定的分子结构相结合，18F-FPCIT探针能够在生物体内实现精准的定位和示踪，为研究者提供关于生物过程、疾病发展和药物作用机制的宝贵信息。在疾病诊断方面，18F-FPCIT探针可用于...
11C-DTBZ分子探针|11C-二氢丁苯那嗪|分子靶点:VMAT2 中文名称:11C-二氢丁苯那嗪 纯度:95%+ 储藏条件:-20°C下避光保存 用途:科研 状态:固体/粉末/溶液 分子式 【相关产品】 18F-FMISO核素分子探针18F-氟咪索硝唑分子靶点:乏氧显像 18F-ML10核素分子探针18F-氟咪索硝唑分子靶点:凋亡显像 ...
11C-DTBZ and 18F-FDG PET measures in differentiating dementias. J Nucl Med. 2005; 46:936-944. [PubMed: 15937303]Koeppe RA, Gilman S, Joshi A, Liu S, Little R, Junck L, et al. 11C-DTBZ and 18F-FDG PET measures in differentiating dementias. J Nucl Med 2005;46(6):936–944....
synthesis of (+)-α-[ 11 C]dihydrotetrabenazine ([ 11 C]DTBZtargeting of vesicular monoamine transporter type 2 (VMAT2Introduction Synthesis Procedures Quality Control Procedures Discussion Chemical Abstracts Nomenclature (Registry Number) References and Notes...
Tong J , Wilson AA , Boileau I , Houle S , Kish SJ ( 2008 ) Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration . Synapse 62 : 873 – 876 ....
Gilman, S, Giordani, B, Albin, R, ,Koeppe, R, Burke, J, Kilbourn,M, Frey , K. Mild dementia evaluated with [11C] DTBZ and [11C] PIB positron emission tomography. Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD), July, 2011....
Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, et al. Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18 F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol 2011;13: 973-84....