STIMULATION OF 11B-HSD2 EXPRESSION TO IMPROVE HORMONAL THERAPY OF STEROID-DEPENDENT DISEASEA method of treating a steroid-dependent disease in a subject is described. The method includes providing steroid hormonal therapy to the subject while inhibiting glucocorticoid receptor activity, or by stimulating...
Hydroxysteroid Dehydrogenase, 11-beta, Type II (11b-HSD2) 中文名: 中文别名: CBNumber: CB7974892 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商2 Hydroxysteroid Dehydrogenase, 11-beta, Type II (11b-HSD2)化学性质 安全信息 ...
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摘要: 目的 探讨复方甘草酸苷片对局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS)大鼠肾功能的保护作用及对醛固酮合成酶(CYP11B2)和11β-羟化甾体脱氢酶(11b-HSD2)基因表达的影响。方法 采用单侧肾切除合并尾静脉注射阿霉素构建FSGS模型,实验分成正常组、模型组、复方甘草酸苷片组、联合干预(复方甘...
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Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with (1S,4S)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]h... S Sheriff 被引量: 0发表: 2014年 An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell ...
CYP11B基因突变导致皮质醇合成障碍,并由于去氧皮质酮(DOC)堆积引起高血压,但肾上腺性激素合成通路无障碍,因而合成过多的雄激素引起女性男性化。由于过多的11-DOC也具有盐皮质激素作用,故导致高血压和低血钾。CYP17缺乏症因CYP17A基因突变导致皮质醇合成不足,ACTH分泌增多,盐皮质激素特别是11-DOC合成增加引起高血压...
STIMULATION OF 11B-HSD2 EXPRESSION TO IMPROVE HORMONAL THERAPY OF STEROID-DEPENDENT DISEASEA method of treating a steroid-dependent disease in a subject is described. The method includes providing steroid hormonal therapy to the subject while inhibiting glucocorticoid receptor activity, or by stimulating...
11b-HSD2 inhibition by the pesticide thiram: The role of cysteine residuesMeyer, A.Odermatt, A.TOXICOLOGY LETTERS
Abstract: 149 ACCELERATED ATHEROSCLEROSIS WITH 11B-HSD2-DEFICIENCY IS ASSOCIATED WITH INCREASED INFLAMMATION IN EARLY STAGES OF PLAQUE DEVELOPMENTMineralocorticoid receptor (MR) activation is proinflammatory and proatherogenic. Antagonism of MR improves survival in humans with congestive heart failure caused ...