A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme....
Walker BR, Seckl JR (2004) 11β-Hydroxysteroid dehydro- genase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease. Expert Opin Ther Targets 7:771-783B.R. Walker, J.R. Seckl, 11β-Hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in metabolic ...
11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a NADPH-dependent enzyme highly expressed in the liver and adipose tissue. In most intact cells and tissues it functions as a reductase (to convert inactive cortisone to active cortisol). It has been hypothesized that tissue-specific ...
Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1Thomas D AicherMark Joseph ChicarelliRonald Jay HinklinHongqi TianOwen Brendan Wallace...
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Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase. The impact of hexose-6-phosphate dehydrogenase (H6PDH) on 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 activity was investigated upon coexpression i... AG Atanas...
We examined the effects of eplerenone on body weight and adipose tissue 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1) and glucocorticoid receptor (GR) gene expression in SHRSP. Methods: Male Wistar-Kyoto (WKY) rats and SHRSP were fed a high sodium diet or normal sodium di...
Hydroxysteroid Dehydrogenase, 11-beta, Type I (11b-HSD1) 推荐供应商 我要询价 先进技术工业有限公司 联系电话:(852) 23902293 电子邮件:sales@advtechind.com CB指数:75 网址:www.advtechind.com 相关信息:产品目录(6523) 用户评价(35) Tag: Hydroxysteroid Dehydrogenase, 11-beta, Type I (11b-HSD1)...
<div p-id="p-0001">The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibi
Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of ... AG Atanasov,AA Dzyakanchuk,RAS Schweizer,... - 《Febs Letters》 被引量: 76发表: 2006年 Pharmacological Bases of Coffee Nutrients for Di...