hydroxysteroid dehydrogenase 1 for the treatment of diabetes, Obesity and dyslipidemia characterized because they comprise a therapeutically effective amount of a compound represented by the formula (1) or a Salt or solvate thereof far Mac u00e9uticamente acceptableWhere a and B can be taken ...
Walker, B.R. and Seckl, J.R. (2003) 11beta-Hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in metabolic and neurodegenerative disease. Expert Opin Ther Targets 7, 771-83.Walker, Brian, R., " 11beta-Hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in ...
Newcastle illness infection, and vesicular stomatitis virus (Ming and Yin, 2013). It is believed that the effect of GA on digestion is caused by inhibition of 11-beta-hydroxysteroid dehydrogenase type 1, which decreases the activity of hexose-6-phosphate dehydrogenase. Consequent...
Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1Thomas D AicherMark Joseph ChicarelliRonald Jay HinklinHongqi TianOwen Brendan Wallace...
The present invention relates to inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipi
We examined the effects of eplerenone on body weight and adipose tissue 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1) and glucocorticoid receptor (GR) gene expression in SHRSP. Methods: Male Wistar-Kyoto (WKY) rats and SHRSP were fed a high sodium diet or normal sodium di...
Barf & Williams, “Recent Progress in 11β-Hydroxysteroid Dehydrogenase Type 1 (11-β-HSD1) Inhibitor Development”, Drugs Fut 2006 31(3):231-243. Chang et al., “Association of Intraocular Pressure With the Metabolic Syndrome and Novel Cardiometabolic Risk Factors”, Eye (Lond). 2010:24(...
Human 11 beta-hydroxysteroid dehydrogenase-types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase belong to a large family of oxidoreductases that includes human dihydropteridine reductase and Streptomyces hydrogenans 20 beta-hydroxysteroid dehydrogenase, for which 3D structures are available. Almost...
HSD17B11, NT (HSD17B11, DHRS8, PAN1B, Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase XI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, ...
Compounds of the formula (I) useful as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors Inventors: Jaroskova, Libuse (Vosselaar, BE) Linders, Joannes Theodorus Maria (Eindhoven, NL) Van Der, Veken Louis Jozef Elisabeth (Vosselaar, BE) Willemsens, Gustaaf Henri Maria (Beerse, BE) ...