The first, and short-step, syntheses of S and R enantiomers of 10-oxo-11( E )-octadecen-13-olide ( 1 ) and its seco-acid 2 , cytotoxic fatty acid derivatives from corn, were achieved from linoleic acid ( 3 ) by the combined use of lipoxygenase-catalyzed asymmetric oxygenation and coba...