Bars = 10 μm (left) and 2 μm (right). Western blotting: lack of effect of Sig-1R knockdown on IP3R1 degradation. (F) Effect of IP3R3 knockdown on ATP-induced Ca2+ influx to mitochondria. n = 5 in tracing (error bar = SEM). Insets are IB of siRNA-transfected cells. (G) ...
Pridopidine treatment completely reverts this H2O2-induced loss of ΔΨm (p = 0.001), showing a TMRM signal similar to YAC128 neurons unchallenged by H2O2 (comparing the two right bars) (Fig. 4e). In order to test the protective effect of pridopidine in a human model, the previous ...
(ETMF) of the Ag-2 B-X system has a negative slope and decreases by approximate to 40% over the 2.43-2.58 angstrom range of internuclear distance The ETMF shows some nonlinear structure, however, the empirical error bars suggest that a linear model is appropriate, thus allowing the r...
The scale bars are 500 and 100 nm. (i,j) Quantitative analysis of the distance (n = 124–132; 3 mice per group) (i) and contact proportion (n = 32–34; 3 mice per group) (j) of ER-mitochondria associations. The data were presented as mean ± SEM and analyzed using one-way ...
A Pareto chart is a type of chart that contains both bars and a line graph, where individual values are represented in descending order by bars, and the cumulative total is represented by the line. In this way, the chart visually depicts which situations are more significant. The Pareto Prin...
(c) Fluorescence recoveries after photobleaching curves of mSigR1-transfected cells show a clear decrease of the mobile fraction as compared to cell transfected with pcDNA or wtSigR1. Error bars indicate the S.E.M.; (right) the comparison of the mobile fractions in pcDNA, wtSigR1 and mSigR1...
Scale bars, 100 μm. (A) One-way ANOVA p = 0.0002, F(3,28) = 9.005; (F) one-way ANOVA p = 0.0005, F(3,28) = 8.049. Post hoc Tukey test, p < 0.05 asterisk, versus saline; number sign, versus sham Treatment with Pridopidine Is Not Effective in Sigma-1 KO Mice We next ...
This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene exp
(ETMF) of the Ag-2 B-X system has a negative slope and decreases by approximate to 40% over the 2.43-2.58 angstrom range of internuclear distance The ETMF shows some nonlinear structure, however, the empirical error bars suggest that a linear model is appropriate, thus allowing the r-...
Error bars in b represent s.e.m. Full size image Intracellular localization of PGRMC1 and sigma-2 receptors The intracellular localization of PGRMC1 and sigma-2 receptors was compared using confocal microscopy. PGRMC1 proteins were visualized with an anti-PGRMC1 antibody, whereas sigma-2 ...