1-Methyl-4-phenylpyridinium (ion) (MPP+) is the ultimate toxic agent formed by metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). MPTP, metabolized to MPP+, is a dopamine neurotoxin, inducing parkinsonism. It was discovered as a result of clandestine synthesis of ...
英文别名: MPP+ IODIDE;1-METHYL-4-PHENYLPYRIDINIUM IODIDE中文名: 中文别名: CBNumber: CB4166683 分子式: C12H12IN 分子量: 297.13 MOL File: Mol file 化学性质 安全信息 用途 价格 供应商 14 1-METHYL-4-PHENYLPYRIDINIUM IODIDE化学性质 溶解度: 0.1 M HCl: soluble 形态: solid 颜色: yellow ...
中文名称: MPP-D3碘 中文同义词: MPP-D3碘;MPP-D3 碘化物 英文名称: MPP-d3 Iodide (1-Methyl-4-phenylpyridiniuM-d3 iodide) 英文同义词: MPP-d3 Iodide (1-Methyl-4-phenylpyridiniuM-d3 iodide) CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览MPP-d3 Iodide (...
To investigate the effects of acute MPP+ exposure on neuronal DA homeostasis, we measured stimulation-dependent DA release and non-exocytotic DA efflux from mouse striatal slices and extracellular, intracellular, and cytosolic DA (DAcyt) levels in cultured mouse ventral midbrain neurons. In acute ...
英文名 1-METHYL-4-PHENYLPYRIDINIUM IODIDE 英文别名 1-METHYL-4-PHENYLPYRIDINIUM IODIDEMPP+ IODIDE 化学式 C12H12IN 分子量 297.13 溶解度 0.1 M HCl: 可溶 外观 固体 颜色 yellow 危险品标志 T - 有毒物品风险术语 R23/24/25 - 吸入、皮肤接触及吞食有毒。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。
We have studied the interaction of coenzyme Q with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its metabolites, 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP(+)) and 1-methyl-4-phenylpyridinium (MPP(+)), the real neurotoxin to cause Parkinson's disease. Incubation of MPTP ...
In this study, we investigated the molecular mechanisms of toxicity of 1-methyl-4-phenylpyridinium (MPP(+)), an ultimate toxic metabolite of a mitochondrial neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, that causes Parkinson-like symptoms in experimental animals and humans. We used ...
MTT assay of the differentiated PC12 cells. (a) Cell viability after the treatments of curcumin, and cyclocurcumin alone (for 24 hours) shows no cytotoxic effects; (b) the cell viability increased significantly after the treatment of the combination of curcumin and MPP+in comparison with thos...
方法:以1-甲基-4-苯基-吡啶离子(1-methyl-4-phenylpyridiniumion,MPP+)介导的SH-SY5Y细胞损伤模型为帕金森病细胞模型,观察不同浓度肉苁蓉提取物对模型细胞生存率、生长抑制和DNA损伤诱导基因153(growth arrest-and DNAdamage-induced gene153,GADD153)及其蛋白表达的影响。 2. Objective To investigate the expression...
摘要: Aim: To explore the effect of melatonin on PC12 cell death induced by 1-methyl-4-phenylpyridinium (MPP + ).关键词:PC12 cells melatonin 1-methyl-4-phenylpyri-dinium glucose DOI: 10.1111/j.1745-7254.2005.00004.x 被引量: 22 ...