1-Methyl-4-phenylpyridinium (ion) (MPP+) is the ultimate toxic agent formed by metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). MPTP, metabolized to MPP+, is a dopamine neurotoxin, inducing parkinsonism. It was discovered as a result of clandestine synthesis of ...
aCan I go with you? 我可以去与您?[translate] a1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells 1甲醇4 phenylpyridinium离子导致内质蜂巢胃重音 通过糖朊synthase激酶3 beta活化作用在PC12细胞[translate]...
方法:以1-甲基-4-苯基-吡啶离子(1-methyl-4-phenylpyridiniumion,MPP+)介导的SH-SY5Y细胞损伤模型为帕金森病细胞模型,观察不同浓度肉苁蓉提取物对模型细胞生存率、生长抑制和DNA损伤诱导基因153(growth arrest-and DNAdamage-induced gene153,GADD153)及其蛋白表达的影响。 2. Objective To investigate the expression...
1-Methyl-4-phenylpyridinium ion (MPP+) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP+ stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of oka...
The neuroprotective effects of tubuloside B, one of the phenylethanoids isolated from the Chinese herbal medicine Cistanche salsa, on 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis and oxidative stress in PC12 neuronal cells were investigated. PC12 cells treated with MPP+ underwent apopto...
Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway X. Chen, “Curcumin Protects PC12 Cells against 1-Methyl-4-phenylpyridinium Ion-Induced Apoptosis by bcl-2-Mitochondria-ROS-iNOS Pathway,” Apoptosis, ... J Chen,XQ Tang...
1989: Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion: dramatic effect of β-mercaptoethanol on substrate turnover and enzyme inactivation Journal of Biological Chemistry 264(36): 21516-...
方法:以1-甲基-4-苯基-吡啶离子(1-methyl-4-phenylpyridiniumion,MPP+)介导的SH-SY5Y细胞损伤模型为帕金森病细胞模型,观察不同浓度肉苁蓉提取物对模型细胞生存率、生长抑制和DNA损伤诱导基因153(growth arrest-and DNAdamage-induced gene153,GADD153)及其蛋白表达的影响。 2. Objective To investigate the expression...