溶解性数据 for 1-Deazaadenosine 溶剂最高浓度 mg/mL最高浓度 mM 溶解性 DMSO 6.66 25制备储备液 for 1-Deazaadenosine 以下数据基于产品分子量 266.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to ...
Chemical Name1-deazaadenosine CAS No.14432-09-8 Molecular FormulaC11H14N4O4 Molecular Weight266.25326 PSA126.65 LogP-0.18 (Predicted) PubChemID159738 Synonyms 1-deazaadenosina; 1- 데 아자 아데노신; 1-デアザアデノシン; 1-Deazaadenosin; 1-déazaadénosine; 3-beta-D-Ribofuranosyl...
Fusion of 7-chloroimidazo[4,5- b ]pyridine (IV, 6-chloro-1-deazapurine) with tetra- O -acetyl-β- D -ribofuranose (V), gave predominantly the tri- O -acetyl derivative of 7-chloro-3-β- D -ribofuranosylimidazo[4,5- b ]pyridine (β-VI) and a small amount of the corresponding ...
Vittori S, Lorenzen A, Stannek C, Costanzi S, Volpini R, IJzerman AP, Kunzel JK, Cristalli G (2000) N -Cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A 1 adenosine receptor. J Med Chem 43:250–260...
A novel route for the preparation of 7-amino-3-(-D-ribofuranosyl)-3H-imidazo [4,5-b] pyridine (1-deazaadenosine) has been developed. Synthesis of 5-deoxy-5-isobutylthio-1-deazaadenosine (1-deazaSIBA) and S-(1-deazaadenosyl)-homocysteine (1-deazaSAH) is also described.doi:10.1080/...
There was a gradual loss of stored RMCP-II in BMMC that were co-cultured with 3T3 cells, but the fibroblast microenvironment did not induce a detectable increase in the low levels of the connective tissue mast cell (CTMC)-associated proteinase, RMCP-I, in the BMMC. Nor did 3T3 cell co-...
常用名 1-Deazaadenosine 英文名 1-Deazaadenosine CAS号 14432-09-8 分子量 266.25300 密度 无资料 沸点 无资料 分子式 C11H14N4O4 熔点 无资料 闪点 无资料 2、1-Deazaadenosine技术资料: 体外研究 1-去氮腺苷作为HeLa、KB、P388和L1210白血病细胞株生长的抑制剂,在体外表现出良好的活性,ID50值在0.34μM...
The reaction of 3-deazaadenosine (3) with 2-acetoxyisobutyryl bromide yielded a mixture of cis and trans 2′,3′-ha-lo acetates which was convertcd into olefinic nucleoside (1) on treatment with a Zn/Cu couplc and then with methanolic ammonia. The 2′,3′-dideoxy-3-deazaadenosine (2...
we found that the parent 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside (GS-441524) was more potent than RDV against SARS-CoV-2 in vitro.3As a continuing effort to improve druggability and oral bioavailability of GS-441524,4herein we report the preclinical characterization and anti-SARS-Co...
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