1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, derived chemically from choline plasmalogens of beef heart, has been shown to possess powerful antihypertensive activity (Blank, M. L., Synder, F., Byers, L. W., Brooks, B., and Muirhead, E. E. (1979) Biochem. Biophys. Res. Commun. 90,...
Touqui L, Jacquemin C, Dumarey C, Vargaftig BB: 1- O -Alkyl-2-alkyl-2-acyl- sn -glycero-3-phosphocholine is the precursor of platelet-activating factor in stimulated rabbit platelets: evidence for an alkylacetyl-glycero-phosphocholine cycle. Biochim Biophys Acta 1985; 833: 111–118....
McIntyre +,S.M. Prescott + 摘要: The specific precursor for platelet-activating factor, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine, constitutes 10 per cent of the 1-radyl-2-acyl-sn-glycero-3-phosphocholines in endothelial cells. Stimulation of endothelial cells results in accumulation of ...
Because diradylglycerols with short fatty chains are absorbed in the intestine and react with cytidine diphosphate-choline in the enterocytes, it is concluded that formation of such PAF mimics as 1-O-alkyl-2-(omega-oxo)acyl-sn-glycerophosphocholine from unsaturated dietary DAGE is a realistic ...
In particular embodiments, the lipids are charged lipids. As used herein, the term “charged lipid” includes, but is not limited to, those lipids having one or two fatty acyl or fatty alkyl chains and a quaternary amino head group. The quaternary amine carries a permanent positive charge. ...
The present invention relates to novel 1-O-alkyl-2-O-acylglycero -3-phosphocholines of the general formula I and to processes for their preparation and their use in pharmaceutical preparations.BETZING, HANS, DIPL.-CHEM. DR., KERPEN, DELAUTENSCHLAEGER, HANS-HEINER, DIPL.-CHEM. DR.PROP,...
Five main products were formed: 1-alkyl-2-acyl-GPE; 1-alkyl-2-acyksn-glycero-3-phosphocholine (1-alkyl-2-acyl-GPC); 1-alkenyl-2-acyl-GPE (ethanolamine plasmalogen); 1-alkenyl-2-acyl-GPC (choline plasmalogen); and 1-alkyl-glycerol. Acylation of the substrate was the main reaction ...
The existence of ether-linked phospholipids, including 1- O -alk-1′-enyl-2-acyl and 1- O -alkyl-2-acyl- sn -glycero-3-phosphocholines and ethanolamines in bonito Euthynnus pelamis (Linnaeus) white muscle, was investigated by gas chromatography and gas chromatography-mass spectrometry. ...
1- O -alk-1′-enyl-2-acyl and 1- O -alkyl-2-acyl glycerophospholipids in white muscle of bonito Euthynnus pelamis (Linnaeus)doi:10.1007/BF02535142The existence of ether-linked phospholipids, including 1-O-alk-1′-enyl-2-acyl and 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholines and ...
Molecular species of 1- O -alk-1′-enyl-2-acyl-, 1- O -alkyl-2-acyl-, and 1,2-diacyl- sn -glycero-3-phosphoethanolamine (EPL) and sn -glycero-3-phosphocholine (CPL) of Japanese oyster Crassostrea gigas were analyzed by selectedion monitoring gas chromatography/mass spectrometry using ...