In fact, this proteolysis method has been successfully used on several DDR proteins, such as PARP2, to uncover disordered regions (Riccio, Cingolani, & Pascal, 2016). The crystal structure of human PARP1 in complex with DNA (PDB: 4DQY) reveals that PARP1 domains collapse into a network ...
Introduction of chloro substituents at meta- and para-positions of the phenyl ring (8b and 8c) were well tolerated, in contrast to ortho-substitution. The addition of the methylamino group in para-position (8d) proved to be more favorable in BRCA-deficient HeLa cells than the addition of ...
T. et al. Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. EMBO Mol. Med. 4, 515–527 (2012). 57. Moudry, P. et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J. Cell ...
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Cohen-Armon M, Yeheskel A, Pascal JM. Signal-induced PARP1-Erk synergism mediates IEG expression. Signal Transduct Target Ther. 2019;4:1. Google Scholar Oei SL, Shi Y. Transcription factor Yin Yang 1 stimulates poly(ADP-ribosyl)ation and DNA repair. Biochem Biophys Res Commun. 2001;284...
the para channel’s sequence and function would be more similar to known NaVchannels. Thus, recent literature refers to this channel as NaV1. NaV1 is known as the principal target for sodium channel-specific pyrethroid insecticides20. In addition, mutations linked to knockdown resistance to pyreth...
Pascal,來自多明尼加共和國 商務旅客 高級房 2021年9月入住 1 晚 Buen hotel pero con internet pesimo” Puntos positivos: buenas habitaciones, pero un poco oscuras,, buen bufet de desayuno, comida y cena, zona de piscina/ bar agradable, personal amable Puntos negativos: los tramites en la ...
Btw, do you know how to train with other datasets, for example PASCAL? Seems they use RLE encoding for the masks instead of polygons. I read it somewhere in the issues that deepmask only works with polygons. My own dataset has binary masks and I think it's not trivial to convert it...
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