First, we analyzed the conformation of βarr1 without receptors. In the absence of receptors, βarr1 adopts the basal state, in which the inactive conformation is maintained and no signal transduction activity is detected6. In the basal state, well-resolved resonances derived from the Ile δ1...
It was suggested that its peripheral antinociceptive activity is associated with attenuated production and/or release of NO and various pro-inflammatory mediators, while central antinociceptive activity seems to be unrelated to the opioidergic system, but could involve, at least in part, an interaction...