总结:李朝军课题组发展了钌催化腙类化合物与不饱和共轭酮的区域选择性1,6-共轭加成。该反应底物的适用范围广,原料简单易得。 论文信息: Ruthenium(II)-catalyzed regioselective 1,6-conjugate addition of umpolung aldehydes as carbanion equivalents Hyotaik Kang and Chao-Jun Li* Chem. Sci.DOI: 10.1039/d1s...
The 1,6-conjugate addition of nitromethane to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones was accomplished and led mainly to the corresponding 尾-(nitromethyl) chromones. (E)-5'-(Nitromethyl)-3'-styryl-[1,1'-biphenyl]-2-ol and 3'-aryl-2'-...
Catalytic asymmetric conjugate allylation of unsaturated carbonyl compounds is usually difficult to achieve, as 1,2-addition proceeds dominantly and high asymmetric induction is a challenging task. Herein, we disclose a copper(I)-NHC complex catalyzed asymmetric 1,6-conjugate allylation of 2,2-dimethyl...
KGaA, Weinheim The 1,6-conjugate addition of nitromethane to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones was accomplished and led mainly to the corresponding β-(nitromethyl)chromones. (E)-5′-(Nitromethyl)-3′-styryl-[1,1′-biphenyl] -2-ol and 3′-aryl-2′-nitro...
diastereoselectivity (entry 11). Heteroaryl-substituted dienylN-acylpyrroles were also amenable to this conjugate addition protocol (entries 12 and 13). Not only δ-aromatic but also δ-alkynyl dienyl acylpyrrole3nwere well accommodated to this system to afford desired 1,6-adductRR-4anin 92% ...
总结:李朝军课题组发展了钌催化腙类化合物与不饱和共轭酮的区域选择性1,6-共轭加成。该反应底物的适用范围广,原料简单易得。 论文信息: Ruthenium(II)-catalyzed regioselective 1,6-conjugate addition of umpolung aldehydes as carbanion equivalents Hyotaik Kang and Chao-Jun Li* ...
Conjugate addition of pyrrolidine or piperidine to methyl crotonate, and hydrolysis of the resulting methyl butyrates gave the (+/-)-3-pyrrolidino or piper... MY Essawi - 《Pharmazie Die》 被引量: 10发表: 1999年 Synthese von 5-Alkyliden-3-pyrrolin-2-onen / Synthesis of 5-Alkylidene-3-...
Figure 6. Loss of bbln-1 compromises the integrity of the endotube Ultrastructure of the apical domain (A and B) and apical junctions (C and D) in intestinal cells of bbln-1(+) and bbln-1(null) adult animals visualized by transmission electron microscopy. Boxed region is shown enlarged,...
ZYZ-168 is a novel conjugate of Leonurine (an alkaloid extracted from a traditional Chinese medicine called Leonurus)20 with S-Propargyl-L-cysteine (SPRC, also called as ZYZ-802)21. The protective effects of ZYZ-168 were tested using primary cultured cardiac fibroblasts in addition to a well-...
(Thermo Fisher Scientific) was used according to the manufacturer’s instructions: in which live keratinocytes were labeled with the fluorescent cholera toxin subunit B (CT-B) (labels gangliosides at the plasma membrane) by incubating cells with the CT-B conjugate working solution for 10 min ...