4-dihydroxy-2-naphthoate (DHNA;Figure 2), which supplies the 1,4-naphthalenoid ring for menaquinone in most bacteria and for phylloquinone in all plants. In some plants, DHNA is also the precursor for specialized 1,4-NQs, such as lawsone (2-hydroxy-1,4-NQ;Figure 2) and juglone...
highest MK-7 production (50 mg/L) was obtained by overexpressing the MK-7 pathway genemenAencoding 1,4-dihydroxy-2-naphthoate heptaprenyltransferase withdxs,dxr, andidi. The accumulation of the MEP pathway intermediate metabolitesDXP, MEP, and MEcPP have been found by metabolite profiling, ...
Another notable finding from our stool metabolomic analysis was an enrichment of menaquinol-8 biosynthesis III and 1,4-dihydroxy-6-naphthoate biosynthesis II in on-therapy samples from participants treated with CBM588. Both of these pathways have been implicated in the vitamin K2 biosynthesis by int...
Diverse naphtho[1,2-b]furan-3-carboxamide derivatives 12a–12q were synthesized in high yield via the novel Re2O7-catalyzed formal [3+2] cycloaddition of 1,4-naphthoquinones with β-ketoamides as the key step. This methodology offers several advantages, such as environmentally benign character...
Hierarchical clustering analysis was performed based on the log-transformed FPKM values using R studio58with hclust function to analyse DEGs identified between different tissue groups related to annotated genes involved in the 1,4-dihydroxy-2-naphthoate (DHNA) biosynthesis pathway inI. balsaminaas well...
similar geranyl pyrophosphate synthase Rv0534c menA 4-dihydroxy-2-naphthoate octaprenyltransferase Rv0548c menB naphthoate synthase Rv0553 menC o-succinylbenzoate-CoA synthase Rv0555 menD 2-succinyl-6-hydroxy-2,4-cyclo- hexadiene-1-carboxylate synthase Rv0542c menE o-succinylbenzoic acid-CoA ligase...
The OSB pathway The OSB pathway consists of a core set of seven reactions that convert chorismate to 1,4-dihydroxy-2-naphthoate (DHNA; Figure 2), which supplies the 1,4-naphthalenoid ring for mena- quinone in most bacteria and for phylloquinone in all plants. In some plants, DHNA is...