The membrane-integrated synthase FKS is involved in the biosynthesis of 尾-1, 3-glucan, the core component of the fungal cell wall. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp. Unfortunately, the mechanism of action of FKS remains enigmatic ...
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains eni...
Analysis of temperature-sensitive mutants of Fks1p identified functional domains in the catalytic subunit of 1,3-β-glucan synthase (Dijkgraaf et al., 2002). Fks1p has a four-domain structure: an N-terminal ∼400 amino acid cytosolic tail involved in (1,3)-β-glucan synthase activity, a...
Mutations that confer acquired EC resistance in Saccharomyces cerevisiae and other normally susceptible yeast species have been mapped to the Fks1 gene; among these is the mutation of residue 639 from Phe to Tyr (F639Y) within a region......
b-1,3- Glucan synthase (GS), an enzyme localized in the plasma membrane, catalyzes the synthesis of b-1,3-glucan, a major polymer component of the cell wall of Candida albicans and other fungi [9]. The cell wall serves as a protective barrier for the fungal cell and is essential for...
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp. Unfortunately, the mechanism of action of FKS remains enigmatic and...
mutations in FKS1 confer hypersensitivity to the immunosuppressants FK506 and cyclosporin A, while mutations in ETG1 confer resistance to the cell-wall-active echinocandins (inhibitors of 1,3-beta-D-glucan synthase) and, in some cases, concomitant hypersensitivity to the chitin synthase inhibitor ni...
作者: F Beta,Dglucan synthesis 摘要: The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi. Synthesis of the linear polymer is catalysed by UDP-glucose beta(1,3)-D-glucan beta(3)-D-glucosyltransferase. Because this enzyme has a key role in fungal cell-...
653 1,3-beta-glucan synthase component FKS1 FKS1 215 6 654 DNA replication licensing factor MCM6 MCM6 113 6 655 Serine/threonine-protein kinase KIN3 KIN3 51 5 656 Mitochondrial clpX-like chaperone MCX1 MCX1 58 6 657 Tricalbin-1 TCB1 134 3 658 Transketolase 1 TKL1 74 7 659 T-comp...
MDBK牛肾细胞 品牌:齐一生物 产品名称:MDBK牛肾细胞 英文名称:MDBK Cell 产品货号:QYL-070207 包装规格:1支 抗体类别:细胞及细胞培养试剂 用途类别:科研检测 贮存方法:冷藏保存 产地:上海 厂家:齐一生物科技(上海)