The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocan
Fks1p and Fks2p are catalytic subunits of 尾-1,3-glucan synthase, which synthesize 尾-1,3-glucan, a main component of the cell wall in Saccharomyces cerevisiae . Although Fks1p and Fks2p are highly homologous, sharing 88.1% identity, it has been shown that Fks2p is more sensitive than ...
Analysis of temperature-sensitive mutants of Fks1p identified functional domains in the catalytic subunit of 1,3-β-glucan synthase (Dijkgraaf et al., 2002). Fks1p has a four-domain structure: an N-terminal ∼400 amino acid cytosolic tail involved in (1,3)-β-glucan synthase activity, a...
Jr ( 2001 ) A putative plant homolog of the yeast β-1,3-glucan synthase subunit FKS1 from cotton ( Gossypium hirsutum L.) fibers . Planta , 213 , 223 – 230 .A putative plant homolog of the yeast β-1,3-glucan synthase subunit FKS1 from cotton (Gossypium hirsutum L.) fibers[J]...
Different from our previous results [10], RhoA (accession number: OBZ71711, MW 59.37 kDa) was matched to the protein band at 60 kDa, which showed a similar function of Rho1 as a GTP-binding protein and a predominant regulatory component regulating β-1, 3-glucan synthase activity. Fig. ...
Enzyme Activity:endo-1,3(4)-β-Glucanase EC Number:3.2.1.6 CAZy Family:GH16 CAS Number:62213-14-3 Synonyms:glucanendo-1,3(4)-beta-D-glucosidase Source:Trichodermasp. Molecular Weight:32,000 Concentration:Supplied at ~ 50 U/mL Expression:Purified fromTrichodermasp. ...
The synthesis of β-1,3-glucan, the structural component of the yeast cell wall that gives shape to the cell, occurs at the plasma membrane and is the result of the activity of at least a two-component complex. Fks1p is the catalytic subunit directly responsible for the synthesis of β-...
MDBK牛肾细胞 品牌:齐一生物 产品名称:MDBK牛肾细胞 英文名称:MDBK Cell 产品货号:QYL-070207 包装规格:1支 抗体类别:细胞及细胞培养试剂 用途类别:科研检测 贮存方法:冷藏保存 产地:上海 厂家:齐一生物科技(上海)
The membrane-integrated synthase FKS is involved in the biosynthesis of 尾-1, 3-glucan, the core component of the fungal cell wall. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp. Unfortunately, the mechanism of action of FKS remains enigmatic ...
Therefore, we hypothesized that the extracellular matrix beta-1,3 glucan as a key component. Using a set of genetically modified strains, we linked expression of beta-1,3 glucan synthase gene FKS1 to the manufacture of extracellular glucan. This material is incorporated into an adhesive, ...