1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorg Med Chem 22, 2416–2426 (2014). 12. Cho, Y. S. et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112...
1,1-Dinitro-2-(2,2-dinitro-ethoxy) methoxy)-1-fluoro-ethane 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one, sodium salt 1,1-Dioxide-1,2-benzisothiazolin-3-one 1,1-Dioxidetetrahydrothiofuran 1,1-Dioxidetetrahydrothiophene 1,1-Dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3...
N-Methyl-3-oxo-1,2-benzisothiazole-2(3H)-carboxamideN-Methyl-3-oxo-1,2-benzisothiazole-2(3H)-carboxamide分子量:208.24 密度:N/A 沸点:N/A 熔点:N/A28018-58-8C9H8N2O2S N-(2,6-dimethylphenyl)-1H-pyrazol-4-amineN-(2,6-dimethylphenyl)-1H-pyrazol-4-amine分子量:187.24 ...
coupling prod ucts of 5 -nitro -2 ,l -benzisothiazole-3 一d id o— nium hydrogensulphate with aromatic amines [ J ].Dyes a nd P /g ments,20 07 ,72 :3 92 -4 0 2 . [11]Pavlovi6 G,Racane L,Ci6cak H,et a1.The synthesis and ...
Due to their potent antiviral activity in vitro, several attempts were made to evaluate the potential therapeutic use of zinc ejectors in vivo. To our knowledge, only two zinc ejectors, namely ADA and benzisothiazolone, were tested in clinical studies. Due to its toxicity, assays with the secon...
The present invention relates to compounds of formula I: wherein R1, R2, R3 and R4 are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via int...
[1,2-α]pyridinyl, Benzoxazolyl, Benzisoxazolyl, Benzothiazolyl, Benzisothiazolyl, Benzofuranyl, Benzothienyl, Benzo[2,1,3]oxadiazolyl, Imidazo[2,1-b]thiazolyl, 2,3-Dihydrobenzo[1,4]dioxolyl und Octahydrobenzo[1,4]dioxyl bestehenden Gruppe steht; wobei die Reste jeweils gegebenenfalls ...
The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomo...
Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators United States Patent 10562897 Abstract: The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meani...
2. The compound of claim 1, wherein the compound is of Formula (Ia-i): or a pharmaceutically acceptable form thereof. 3. The compound of claim 1, wherein the compound is of Formula (Ib-i) or (Ib-ii): or a pharmaceutically acceptable form thereof, wherein X1, X2, and X3 are ind...