et al. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes? Diabetes 60, 2588–2597 (2011). 38. Koves, T. R. et al. PPARgamma coactivator-1alpha contributes to exercise- induced regulation of intramuscular lipid droplet...
Identification of 2-aminooxazole amides as acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategyDGAT1 inhibitorsTreatment for dyslipidemiaScaffold hoppingA scaffold hopping strategy was successfully applied in discovering 2-aminooxazole amides as potent DGAT1 inhibitors...
We validated the regulation of two DEGs involved in lipid pathways in rice namely, 1,2-diacylglycerol 3-beta-galactosyltransferase (MGD2) and long-chain-fatty-acid-CoA ligase family protein (LACS1, LOC_Os05g04170) (Fig. 2). The indispensible roles of reactive nitrogen (N) compounds as ...
anti- DGAT1 antibody别 名 hCG_1776018; Phosphoinositide interacting regulator of transient receptor potential channels ; Phosphoinositide-interacting protein; Pirt; PIRT_HUMAN.Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates....
产品介绍 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase acti...
We identified in the RHA1 genome: 14 genes encoding putative wax ester synthase/acyl-CoA:diacylglycerol acyltransferase enzymes (WS/DGATs) likely involved in TAG and wax esters biosynthesis; a total of 54 genes coding for putative lipase/esterase enzymes possibly involved in TAG and wax ester degr...
FATP1/acyl-CoA synthetase and DGAT2/diacylglycerol acyltransferase form a complex at ER-LD contacts for LD expansion (Xu et al., 2012). The FATP1/DGAT2 interaction was also enhanced in VMP1 KO cells (Figure 5G). The ER-resident transmembrane protein BSCL2/Seipin acts at ER-LD contact si...
DAG, diacylglycerol; DNL, de novo lipogenesis; ER, endoplasmic reticulum; GIP, glucose-dependent insulinotropic peptide; GLP-1: Glucagon-like peptide-1; GLP-1RA, Glucagon-like peptide-1 receptor agonist; LD, lipid droplet NEFA, non-esterified fatty acids; TAG, triacylglycerol; VLDL, very low-...
The 1-stearoyl-2-arachidonyl (38:4) form of PI(4,5)P2 is found to be a dominant species across multiple primary mammalian cells [49,50,51,52,53] (Figure 1b). The preference of enzymes involved in the PI cycle, such as diacylglycerol kinase ε (DGKε), for substrates displaying 38...
During gene conversion, genetic information is transferred unidirectionally between highly homologous but non-allelic regions of DNA. While germ-line gene conversion has been implicated in the pathogenesis of some diseases, somatic gene conversion has re