We demonstrate a reproducible increase in 1,2-diacylglycerol, in the absence of a detectable increase in inositol phosphates, in transformed cells containing Ha-ras oncogenes and with different membrane targeting signals for the ras p21 protein. These findings suggest that a source other than ...
Nucleophilic substitution in glycerol derivatives. Part V. Formation of 1,3-diacylglycerol-2-phosphates in the reaction of 1,2-diacyl-3-iodoeoxy-rac-glycerol with silver dibenzyl phosphateThe reaction of 1,2-dipalmitoyl-3-iododeoxy- rac-glycerol with silver dibenzyl phosphate gave 1,2-dipalmitoyl...
(1984a). 1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets. Biochem. Biophys. Res. Commun., 121, 386–391.PubMedCrossRef WATSON, S.P., McCONNELL, R.T. & LAPETINA, E.G. (1984b). The rapid formation of inositol phosphates in human ...
Phospholipase C (PLC)2 is an enzyme that catalyzes the formation of diacylglycerol and inositol 1,4,5-trisphosphates from phosphatidylinositol 4,5-bisphosphates, which are implicated in PKC activation and intracellular Ca2+ mobilization, respectively (1). As one of six mammalian PLC isotypes (β...
Diacylglycerol (DG) pathway甘油二酯途径 Lysophosphatidate溶血磷脂 Glycerophospholipid甘油磷脂 phospholipase (PLA)磷脂酶 Dipalmitoyl phosphatidylcholine二棕榈酰磷脂酰胆碱 Sphingomyelin鞘磷脂 Ceramide神经酰胺 Multiple sclerosis多发性硬化 cholelithiasis胆结石 Gall Bladder胆囊 Sitosterol谷甾醇 β-sitosterol谷固醇 β-er...
Phospholipase C (PLC) enzymes hydrolyze phosphoinositide lipids to inositol phosphates and diacylglycerol. Direct activation of PLCβ by Gαq and/or Gβγ subunits mediates signaling by Gq and some Gi coupled G-protein-coupled receptors ... IJ Fisher,ML Jenkins,GG Tall,... - 《Structure》 被...
The hydrolysis of PIP 2 generates two second messengers, inositol-1,4, 5-trisphosphate(IP 3 ) and sn-1,2-diacylglycerol(DAG)(2). It is known that... H Kawaguchi,M Shoki,H Sano,... - Springer Japan 被引量: 105发表: 1992年 Distribution of the neurons containing inositol 1,4,5-tris...
(PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific...
U. et al. Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nat Commun 5 (2014). 28. Delmas, P., Wanaverbecq, N., Abogadie, F. C., Mistry, M. & Brown, D. A. Signaling Microdomains Define the Specificity of Receptor- Mediated InsP3 Pathways in ...
Basal or unstimulated protein kinase C, phosphatidylserine/diacylglycerol stimulated protein kinase C, and test samples are run in each assay. Protein kinase C extract (1-5 μg of protein; 10 μl); an 8 μl solution of N-2-hydroxyethylpiperazine-N'-2-ethylsulfonic acid (500 mM), ...