Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical success has been limited by on-target, off-tumor activity. Here, we report the development of a tumor-anchored ɑ4-1BB agonist (ɑ4-1BB-LAIR...
The enhanced anti-tumor immunity in immunogenic tumors can be ascribed to the inhibition of PTP1B/PTPN2 in T cells, whereas in cold tumors, Compound-182 elicited direct effects on both tumor cells and T cells. Importantly, treatment with Compound-182 rendered otherwise resistant tumors sensitive...
Itaconate is produced from the mitochondrial TCA cycle enzyme aconitase decarboxylase (encoded by immune responsive gene1; Irg1) that exerts immunomodulatory function in myeloid cells. However, the role of the Irg1/itaconate pathway in dendritic cells (D
Conventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer. Howev
TNFRSF4, also known as CD134 or OX40, is another TNF receptor that was associated with the high-risk group in our analysis. Like 4-1BB, TNFRSF4 is expressed in activated T cells and enhances T cell responses upon ligation.26 Both proteins have previously been detected at high levels ...
Keywords: cardiac stem cells; immortalization; secretome; MCP-1; cardiomyocyte survival 1. Introduction Cardiac Sca-1+ cells showed cardiac stem cell (CSC) properties differentiating into cardiac and endothelial cells, as evidenced by in vitro and in vivo studies [1–5]. Knockdown of Sca-1 ...
Importantly, NK1R expressed by T cells contribute to the fraction of NK1R mobilized to the immune synapse, as segregation of the NK1R inside or near the immune synapse was detected by ImageStream analysis when OT-II T cells were incubated with NK1RKO DCs loaded with OVA323-339 (Figure 1F...
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T cell signaling and function ex vivo (Fig.2). Compound 182 enhanced the antigen-induced activation of CD8+T cells, as assessed by measuring the cell surface levels of the activation markers CD25 and CD69 after challenging OT-I TCR transgenic CD8+T cells with the cognate ovalbumin (OVA) ...
OT-1 T cells killing activity (Supplementary Fig.2l). We also confirmed our observations in human primary cells co-culture system. When co-culturing with CD8+T cells isolated from CRC patients’ peripheral blood mononuclear cells (PBMCs),ID1depletion in TAMs isolated from CRC patients’ tumor ...