消化管傷害性の低いNSAIDsの開発 - COX-2選択的阻害薬とNO遊離型NSAIDs - The use of NSAIDs is associated with a wide array of alterations in the gastrointestinal integrity and function. Various approaches have been taken to deve... 竹内 孝治,田中 晶子 - 《日本薬理学雑誌》 被引量: 0...
However, there are distinct examples of circumstances in which COX-2-derived PGs play a role in the maintenance of the mucosal integrity, and the differentiation of COX-1 and COX-2 is not quite as clear as has been suggested. On the other hand, the rational behind the NO-releasing NSAID...