棘白菌素类1. In recent years,some novel antifungal agents have been developed,including new azoles such as vorriconazole and posaconazole,and echinocandins such as caspofungin and micafungin. 近年来,一些新的抗真菌药物相继问世,包括新三唑类(活力康唑、泊沙康唑等)和棘白菌素类(卡泊芬净、米卡芬净...
棘白菌素类 1. In recent years,some novel antifungal agents have been developed,including new azoles such as vorriconazole and posaconazole,andechinocandinssuch as caspofungin and micafungin. 近年来,一些新的抗真菌药物相继问世,包括新三唑类(活力康唑、泊沙康唑等)和棘白菌素类(卡泊芬净、米卡芬净等)...
a目前治疗侵袭性真菌感染的药物主要有三唑类如氟康唑、伏立康唑、伊曲康唑;多烯类如两性霉素B;棘白菌素类如卡泊芬净等 At present treats the attack fungus infection the medicine mainly to have triazole as for example fluorine Kang Zuo, Fu Likang zuo, Iraq Qu Kang zuo; Polyene as for example amp...
棘白菌素类抗真菌药物米卡芬净和阿尼芬净的合成工艺中包括一个关键步骤:水解除去FR901379分子和棘白菌素B(echinocandin B,ECB)分子的脂肪酸侧链,形成环状的6元多肽核心。FR901379和ECB的水解可以分别被FR901379酰基酶和阿库来菌素A酰基酶(aculeacin A acylase,AAC)催化,因此,FR901379酰基...