Class D ??-Lactamases: A Reappraisal after Five Decades Despite 70 years of clinical use, β-lactam antibiotics still remain at the forefront of antimicrobial chemotherapy. The major challenge to these life-savi... DA Leonard,RA Bonomo,RA Powers - 《Accounts of Chemical Research》 被引量: 97...
(2007) First Report of the Emergence of CTX-M-Type Extended-Spectrum 尾-Lactamases (ESBLs) as the Predominant ESBL Isolated in a U.S. Health Care ... JS Lewis,M Herrera,B Wickes,... - 《Antimicrob Agents Chemother》 被引量: 676发表: 2007年 Characterization of CTX-M and SHV extended...
In vitro studies show that avibactam may restore the broad-spectrum activity of cephalosporins against class A, class C, and some class D β-lactamases. Here we describe the structures of two clinically important β-lactamase enzymes bound to avibactam, the class A CTX-M-15 extended-spectrum ...