尾-Arrestins can act as adapter molecules, coupling G-protein-coupled receptors to proteins involved in mitogenic as well as endocytic pathways. We have previously identified c-SRC as a molecule that is rapidly recruited to the 尾2-adrenergic receptor in a 尾-arrestin1-dependent manner. Recruitme...
Western blotting was used to detect the expression of JNK and p-JNK in the cells, and co-immunoprecipitation (Co-IP) assay was employed to investigate the interaction between β-arrestin1 and Src. RESULTS K562-β1 cells showed significantly greater but ...