因此,只有更好地对移植术后排斥反应进行早期诊断与监测,才能做到个体化免疫抑制应用,减少移植肾过早丢失,提高受者的生存率。 供者来源性细胞游离DNA(donor-derived cell-free DNA,dd-cfDNA)是指器官移植术后受者循环体液中来源于凋亡或...
Detection of donor-derived cell-free DNA (dd-cfDNA) could be performed based on the next-generation sequencing and other techniques. The content of DNA fragments derived from necrotic and apoptotic donor kidney tissues in circulating body fluids could be determined...
肾移植术后排斥反应的早期诊断及治疗对于减少移植物损伤至关重要.供者来源性细胞游离DNA(dd-cfDNA)检测是基于二代测序等技术,通过浓度法及绝对定量法检测循环体液中源于坏死,凋亡的供肾组织DNA片段含量,具有监测同种异体移植物损伤的临床应用潜力.相比传统血清肌酐等检测指标,dd-cfDNA检测可提前数周至数月监测到移植物...