Deposition of aggregated 伪-synuclein (伪-Syn) occurs in familial and sporadic forms of Parkinson's disease. Here, we studied the effect of oligomeric 伪-Syn on one of the major markers of oxidative stress, lipid peroxidation, in primary co-cultures of neurons and astrocytes. We found that ...
How APOE4 drives risk of LBD and whether it has a direct effect on 伪-synuclein pathology are not clear. Here, we generated a mouse model of synucleinopathy using an adeno-associated virus gene delivery of 伪-synuclein in human APOE-targeted replacement mice expressing APOE2, APOE3, or ...
Phosphatidylcholine and Phosphatidylserine Uniquely Modify the Secondary Structure of 伪-Synuclein Oligomers Formed in Their Presence at the Early Stages o... Phosphatidylcholine and Phosphatidylserine Uniquely Modify the Secondary Structure of 伪-Synuclein Oligomers Formed in Their Presence at the Early ...
(2001) Parkinson's disease and other alpha-synucleinopa- thies. Clin. Chem. Lab. Med. 39, 308-... M Goedert - 《Clinical Chemistry & Laboratory Medicine》 被引量: 160发表: 2001年 Parkinsons Disease - Redox Mechanisms Parkinsons disease occurs in 1percent of people over the age of 65 ...
one of these studies has shown an interaction between α-synuclein and one of these SNARes, synaptobrevin, No data is known about the strength of the interaction between α-synuclein and synaptobrevin or if any interaction takes place between α-synuclein and the other SNAREs SNAP25 and syntaxin...