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2001. -Ketoacyl-acyl carrier protein synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analysis of mutations in the active site pocket. Biochemistry 40:9836-9845.McGuire KA, Siggaard-Andersen M, Bangera MG, Olsen JG, von Wettstein-Knowles P (2001) -Ketoacyl...
In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I is an enzyme that catalyzes the chemical reaction: An acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] ightleftharpoons a 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. Thus, the two substrates ...
Structure of beta-ketoacyl-[acyl carrier protein] synthases complexed with inhibitors and methods of use thereofCrystals of FabB-inhibitor complexes are disclosed that allow the three-dimensional structure of the FabB-inhibitor complex to be determined. The use of this structural information to ...
Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthase The enzyme activity responsible for translocation of saturated acyl chains from the 4'-phosphopantetheine of the acyl carrier protein to the active site cy... ...
3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseIsoenzymesFatty AcidsChromatography, GelTwo forms of beta-ketoacyl-acyl carrier protein (ACP) synthetase (designated I and II) have been identified in extracts of Escherichia coli. Synthetase I corresponds to the condensing enzyme that was studied earlier (...
beta-Ketoacyl-[acyl carrier protein (ACP)] synthase forms new carbon-carbon bonds in three steps: transfer of an acyl primer from ACP to the enzyme, decarboxylation of the elongating substrate and its condensation with the acyl primer substrate. Six residues of Escherichia coli beta-ketoacyl-ACP...
In this communication, it is demonstrated that these mutants lack beta-ketoacyl-acyl carrier protein synthase II. The deficiencies in cis-vaccenate synthesis and synthase II are shown to be due to a lesion in the same gene, fabF. Lesions in the fabF gene are found to affect growth only ...
cDNA sequencing revealed an open reading frame for 462 residues comprising the mature protein and a 35-amino acid transit peptide. The deduced amino acid sequence of the mature protein is homologous to the β-ketoacyl-[acyl carrier protein] (ACP) synthase I [3-oxoacyl-ACP synthase; acyl-ACP...
G. et al. The X-ray crystal structure of β -ketoacyl [acyl carrier protein] synthase I. FEBS Lett. 460, 46–52 (1999). 21. Qiu, X. et al. Crystal Structure of β -Ketoacyl-Acyl Carrier Protein Synthase III: A Key Condensing Enzyme in Bacterial Fatty Acid Biosynthesis. J. ...