Factors influencing the stability of alpha-helices and beta-strands in thermophilic ribonuclease H.Thermus thermophilusSolventsEnzyme StabilityProtein ConformationProtein Structure, SecondaryModels, MolecularRibonuclease HHot TemperatureUnderstanding the influence of structural parameters is crucial to enhance the ...
Prediction of transmembrane beta-strands in outer membrane proteins (OMP) is one of the important problems in computational chemistry and biology. In this ... MM Gromiha,S Ahmad,M Suwa - 《Journal of Computational Chemistry》 被引量: 181发表: 2004年 BOCTOPUS: improved topology prediction of ...
We analysed the length distributions of different types of beta-strand in a high resolution, non-homologous set of 500 protein structures, finding differences in their mean lengths. Antiparallel edge strands in strand-turn-strand motifs show a preference for an even number of residues. This propens...
The newly exposed strand then allows a novel beta-sheet interaction to form between the TTR subunits. This interaction and another previously identified subunit association lead to a plausible model for the specific sequence of beta-strands in one of the indefinitely repeating beta-sheets of TTR ...
The general picture of the beta-sheet is that the three central beta-strands are completely intact while the two edge beta-strands are mainly present but certainly weakened. The first five residues of the protein unwind but the C ... L Serrano,A Matouschek,AR Fersht - 《Journal of Molecula...
Strands was introduced in beta form in March, meaning it was still being tested, and was not available in the Games app, only on the Times' desktop or mobile sites. It's updated daily, and presents players with a grid of letters like those in those old-fashioned Word Find books they ...
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To remedy this problem and facilitate de novo prediction of β-sheet containing protein structures, we developed a support vector machine (SVM) approach that classified parallel and antiparallel orientation of β-strands by using the information of interstrand amino acid pairing preferences. Based on ...
Rules (constraints) were determined for four features of beta-sheet packing: (i) whether a beta-strand is at an edge; (ii) whether two consecutive beta-strands pack parallel or anti-parallel; (iii) whether two beta-strands pack adjacently; and (iv) the winding direction of two consecutive...
The present invention relates generally to new compositions of matter and methods of using such compositions of matter for investigational or therapeutic purposes, and more particularly to compositions that a) mimic β-strands, b) block β-sheet dimerization of proteins, c) block protein-protein β...