beta-hydroxyphosphonatessamarium iodideIn the presence of samarium iodide alpha-halophosphonates react with aliphatic carbonyl compounds (aldehydes and ketones) to afford beta-hydroxyphosphonates in fairly good yields under neutral and mild conditions. Lower yields are obtained with aromatic carbonyl ...
Applicants have found that β-hydroxy-γ-aminophosphonates and β-amino-γ-aminophosphonates having Formula I or Formula II, or stereoisomers thereof, (see below; collectively referred to herein as “compounds of the disclosure”) stimulate the production of T-lymphocytes in a subject. Thus, in...
cylindracea and rotease subtilisin in a biphasic system gives (S)-beta-hydroxy-phosphonates (ee 51-92%)enantioselectively.(S)-2-Phenyl-2-hydroxyethyl-and (S)-3-methyl-2-hydroxy-butylhosphonates (ee 96% and 99%,respectively)were transformed into (R)-2-aminophosphonic acids of the same ...
Two alternative routes to methyl and trifluoromethyl substituted beta-amino and beta-hydroxy phosphonates via hydrogenation of vinylphosphonates and via aldol-type addition of ethylphosphonate to trifluoromethyl substituted imines and carbonyl compounds are described.NN Sergeeva...
beta-hydroxyphosphonatessamarium iodideIn the presence of samarium iodide alpha-halophosphonates react with aliphatic carbonyl compounds (aldehydes and ketones) to afford beta-hydroxyphosphonates in fairly good yields under neutral and mild conditions. Lower yields are obtained with aromatic carbonyl ...
Yokomatsu, T,Yoshida, Y,Shibuya, S.Stereoselective synthesis ofβ-oxygenatedα-hydroxy- phosphonates by lewis acid-mediated stereoselective hydrophosphonylation ofα-benzyloxy aldehydes: an application to the synthesis of phosphonic acid analogs of oxyamino acids. Journal of Organic Chemistry . 1994...
Bis-n, nu-dialkylamino phosphoric acid esters of o, o-dialkyl-alpha-hydroxy-belta, beta, belta-trichloroethylphosphonatesComplete Patent Searching Database and Patent Data Analytics Services.doi:US3271480 ASchrader GerhardUS
de la Cruz-Cordero, R.Quinones, C.Gonzalez-Morales, A.CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRYOrdóñez, M. et al., " Highly diastereoselective synthesis of anti-gamma -N-benzylamino-beta-hydroxyphosphonates, " Chemical Communications, 672-673 (2004)....
Compounds of the class of the beta - hydroxyphosphonates and their productionSTURTZ GEORGESSTURTZ GEORGES
The reduction of gamma-N,N-dibenzylamino-beta-ketophosphonates 4 derived from readily available (S)-tribenzylated amino acids teas achieved with catecholborane at -20degreesC affording gamma-amino-beta-hydroxyphosphonates 5 in high diastereoselectivity and good chemical yield. These reactions provide...