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Furthermore, ActRII- betaglycan complexes may be used to generate a new signal different from that initiated by activin signaling via ALK4 and ActRII. The individual nucleus of rat brain, beta-glycan is made of rat pituitary grown, by a special cell types of ovarian and internal testes. ...
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摘要: Betaglycan,a membrane proteoglycan,is a co-receptor for diverse members of the TGF-beta superfamily.It potentiates TGF-beta effects;however,in its soluble form is a pharmacological useful TGF-beta'inhibitor,Membrane betaglycan also functions as the physiologically relevant inhibin receptor.A...
Betaglycan has not been studied in the context of bone metastatic disease previously. Here we report that loss of betaglycan in MSC is sufficient to augment TGFβ signaling, proliferation and migration, and completely blocks the MSC–osteoblast differentiation program. Further, betaglycan was ...
Betaglycan is an accessory receptor for the transforming growth factor-β (TGFβ) superfamily, many members of which play key roles in kidney development. The purpose of this study was to define the role of this co-receptor on fetal murine kidney development. Stereological examination of embryonic...
Betaglycan protein expression in FBN1 mutants pooled was higher than in controls (P=.004) and in DN higher than in HI (P=.015). In DN, significantly higher mRNA expression of FBN1 (P=.014), SMAD7 (P=.019), HSP47 (P=.023), and SERPINE1 (P=.008), but a lower HSPA5 expr...
Finally, betaglycan confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone. The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as co-receptors modulating ligand-receptor sensitivity, selectivity...
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