Beta-catenin (–)/cyclin D1 (–) cases displayed less tumor invasion than the remaining cases. However, there were no significant differences in lymph node metastasis or other clinicopathological findings. Conclusion: Our results indicate that beta-catenin overexpression in the cytoplasm may promote ...
Immunohistochemistry of cyclin D1 showed positive staining in 9 (37.5%) of the 24 parathyroid adenomas. The status of β-catenin, which has recently been identified as a regulator of cyclin D1 transcription, was examined by direct sequencing of exon 3 of the β-catenin gene and ...
In nonmucinous tumors, 9 cases showing overexpression of c-myc or cyclin D1 revealed accumulations of beta-catenin. The accumulation of beta-catenin was not statistically related to clinico-pathological parameters. The association between c-myc overexpression and histological subtype of tumors was ...
1. This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA in various subgroups of acute myeloid leukemia(AML)and to analyze their potential relationship,so as to provide theoretical basis for exploring the role of Wnt/beta-catenin pathway in the pathogenesis...
1.Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma;β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达 2.The modulations ofbeta-cateninand caspase-3 levels were investigated in the KM mouse embryo following maternal treatme.用 RT-PCR 及蛋白质印迹技术,探测了过量维甲酸...
The target genes, c-myc and cyclin D1, were activated by beta-catenin in the hepatocytes. Our study suggests that mutant beta-catenin can promote cell proliferation and cell survival ability, but the stabilized beta-catenin alone is insufficient for completely oncogenic transformation....
ObjectiveHead and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. ...
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most human colon cancers. Loss of functional APC protein results in the a... O Tetsu,F Mccormick - 《Nature》 被引量: 8443发表: 1999年...
The transforming growth factor-alpha and cyclin D1 genes are direct targets of beta-catenin signaling in hepatocyte proliferation. J Hepatol 2011;55:86-95.Torre C, Benhamouche S, Mitchell C, Godard C, Veber P, Letourneur F, Cagnard N, Jacques S, Finzi L, Perret C, Colnot S (2011) ...
Pyrvinium pamoate处理抑制了GSK3β在S9的磷酸化,这可能由AKT介导,并降低了β-catenin及其下游靶点(c-Myc, cyclin D1)的蛋白质水平。Pyrvinium pamoate显著抑制细胞活性和集落形成能力。Pyrvinium pamoate的处理诱导了依赖内源性途径的凋亡,伴随着抗凋亡XIAP和Survivin的下降,以及促凋亡Bax的明显增加。此外,Pyrvinium pamo...