《beta-Arrestins/PIPKIs结合调控GPCR相关信号通路的机制和功能研究》是依托华东师范大学，由王平担任项目负责人的青年科学基金项目。项目摘要 G蛋白偶联受体（GPCR）是一类七次跨膜受体，是目前已知数目最多的细胞表面受体家族。GPCR的信号传导在许多生理病理状态下发挥重要作用。细胞膜中磷脂酰肌醇4、...
RGS proteins, GRKs, and beta-arrestins modulate G protein-mediated signaling pathways in asthma_2021_Nathalie Fuentes 上传人:jrvbib221·上传时间:2022-10-29 继续阅读
The β-arrestins, multifunctional adapter proteins, have the potential to regulate all of these receptor families, although it is unclear as to whether they serve to integrate signaling across all of these different axes. Notably, the β-arrestins have been shown to regulate signaling by a ...
Beta-arrestin1 and beta-arrestin2 were initially identified by sequence homology to visual arrestins and by their ability to bind to and inactivate signaling of the beta-2-adrenergic receptor in a process known as desensitization. While the role of beta-arrestins in desensitization has been known...
上海玉博生物科技有限公司 主要致力于“Rabbit monoclonal [E109] to beta Arrestin 1 (phospho S412) Abcam ab32097 ”的生产销售。多年的“Rabbit monoclonal [E109] to beta Arrestin 1 (phospho S412) Abcam ab32097 ”生产与销售的经验,与各行业新老用户建立了稳定
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nat. Chem. Biol. 14, 126-134. doi: 10.1038/nchembio.2527McCorvy, J. D. et al. Structure-inspired design of β-arrestin-biased ligands for aminer... McCorvy, John D,Butler, Kyle V,Kelly, Brendan,......
Lysophosphatidylcholine activation of the G2A receptor causes beta-arrestin-1, G alpha (q)/11, and G alpha (i)-1 recruitment to the plasma membrane Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TR...
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