The discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) was postulated more than twenty years ago [1,2] when genetic forms of PD were described. Abnormal aggregates of α-syn, such as Lewy bodies (LB) and Lewy neurites, and glial ...
The discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) was postulated more than twenty years ago [1,2] when genetic forms of PD were described. Abnormal aggregates of α-syn, such as Lewy bodies (LB) and Lewy neurites, and glial ...
Parkinson’s Disease (PD) is a chronic and progressive neurodebilitating disorder that affects both motor and non-motor functions. PD is the second most commonly occurring brain disorder after Alzheimer’s disease. The incidence rate of PD was found to be 17 per 100000 per year. The prevalence...
With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US ...
Whether alpha-synuclein in peripheral body fluids can be used for the diagnosis of Parkinson’s disease (PD) remains in controversy. This study evaluates diagnostic potential of alpha-synuclein for PD in various peripheral body fluids using a meta-analysis approach. ...
Parkinson's disease (PD), the most common neurological motor system disorder, which characterised by the irreversible loss of dopaminergic neurones in the substantia nigra pars compacta, and leads to the deficiency of dopamine in the striatum. Deposited Lewy bodies (LBs) in diseased neurones and ...
Alpha-synuclein (SNCA) is crucial in the pathogenesis of Parkinson's disease (PD), yet mutations in the SNCA gene are rare. Evidence for somatic genetic variation in normal humans, also involving the...
Parkinson’s disease (PD) is the second most common late-onset neurodegenerative disease and the predominant cause of movement problems. PD is characterized by motor control impairment by extensive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). This selective dopaminergic ...
Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous system. Lewy bodies can arise from the cell-to-cell propagation of αSyn, which can occur via sequential
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and deg