preformed fibrilssynaptic functionsynucleinopathySynucleinopathies are characterized by the accumulation of insoluble alpha-synuclein (alpha Syn). To test whether alpha Syn aggregates modulate synaptic activity, we used a recently developed model in primary neurons for inducing alpha Syn pathology. We...
Preformed fibrilsPropagationSynucleinopathies are composed of Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Alpha-synuclein (alpha-Syn) forms aggregates mainly in neurons in PD and DLB, while oligodendroglial alpha-Syn aggregates are characteristic of...