Two new p-alkoxycarbonylated palladium bis(phosphinite) PCP pincer complexes are easily prepared and for the first time evaluated as homogeneous catalysts in alpha-arylation of ketone enolates.Apart from the total absence of phenyl-aryl exchange by-products and significantly low catalyst loadings,...
These conditions allow for the synthesis of di- and tri-ortho-substituted biaryls in very short reaction times. This complex also displays very high activity for alpha-ketone arylation and dehalogenation reactions of activated and unactivated aryl chlorides. 展开 ...
ketone arylationmonodentate ligandsNHCpalladiumA general catalytic protocol for the alpha-arylation of aryl ketones has been developed. It involves the use of a preformed, bench-stable Pd-N-heterocyclic carbene pre-catalyst bearing IHept as an ancillary ligand, and allows the coupling of various ...
KETONE ACTIVATION ENABLES METAL-FREE ALPHA-ARYLATION AND ALPHA-OXYAMINATION OF ACETOPHENONESWojciech ZawodnyChristopher TeskeyMagdalena MishevskaMartin VlklBoris MaryasinNuno MaulideProceedings of European Symposium on Organic Chemistry 2019
O. Navarro,N. Marion,Y. Oonishi,R. A. Kelly,S. P. Nolan."Suzuki-miyaura, alpha-ketone arylation and dehalogenation reactions catalyzed by a versatile n-heterocyclic carbene-palladacycle complex". Journal of Organic Chemistry . 2006Navarro O, Marion N and Oonishi Y et al (2006). Suzuki–...
The invention further relates to a process for preparing an asymmetric α-(hetero)arylated or a-vinylated ketone which comprises reacting the tin enolate of the ketone in the presence of catalyst system comprising a ligand of the invention and palladium source. By means of the ligands and ...
This protocol tolerates a variety of alpha-carbonyl alkyl bromides, including primary, secondary and tertiary alpha-bromoalkyl ketone esters.doi:10.1002/adsc.202000363Luo, Shu-ZhengMin, Man-YiWu, Yan-ChenJiang, Shuai-ShuaiXiao, Yu-TingSong, Ren-JieLi, Jin-Heng...
This protocol tolerates a variety of alpha-carbonyl alkyl bromides, including primary, secondary and tertiary alpha-bromoalkyl ketone esters.doi:info:doi/10.1002/adsc.202000363Luo, Shu-ZhengMin, Man-YiWu, Yan-ChenJiang, Shuai-ShuaiXiao, Yu-Ting...
alpha-Functionalization of ketones in an umpolung fashion can be achieved by nucleophilic addition to the oxy-allyl cation intermediate. However, applicable carbon nucleophiles are limited to ones with high nucleophilicity. Additionally, introduction of a leaving group to the alpha-position of ketone ...
A ligand and base-free copper catalyzed synthetic method for the efficient alpha-arylation of aromatic ketones is described. In order to avoid strong bases, ketone-derived silyl enol ethers were employed. Their reaction with diaryliodonium salts as aryl source provided the intermolecular C-C coupling...