The alpha-arrestin ARRDC3 is a recently discovered tumor suppressor in invasive breast cancer that functions as a multifaceted adaptor protein to control protein trafficking and cellular signaling. However, the molecular mechanisms that control ARRDC3 function are unknown. Other arrestins are known to...
Alpha-arrestins and visual/beta-arrestins lack sequence similarity between each other, but share the same tertiary structure of N- and/or C-terminal arrestin-domain25,26, and possess analogous function in trafficking steps of membrane-embedded proteins. However, as the more ancient branch that ...
Correction: Corrigendum: Autophagy-associated alpha-arrestin signaling is required for conidiogenous cell development inBo DongXiaojin XuGuoqing ChenDandan ZhangMingzhi TangFei XuXiaohong LiuHua WangBo ZhouScientific ReportsDong B, Xu X, Chen G, Zhang D, Tang M, Xu F, et al. (2016) Autophagy...
Arrestin-3 binding to JNK1alpha1/JNK2alpha2: modulation of JNK1 and JNK2 activity via scaffoldingNon-visual arrestins scaffold mitogen-activated protein kinase (MAPK) cascades, bringing together three components of MAPK signaling modules. The c-Jun N-terminal kinases (JNKs) are members of MAPK...
Lysophosphatidylcholine activation of the G2A receptor causes beta-arrestin-1, G alpha (q)/11, and G alpha (i)-1 recruitment to the plasma membrane Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TR...
Alpha-arrestins Aly1 and Aly2 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasisCalcineurinE3 ubiquitin ligaseEndocytosisMicroscopyProtein trafficking adaptorsS. cerevisiaeVacuolePhosphatidylinositol (PI) is an essential phospholipid and critical component of ...
The alpha-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC3 in TNBC is important. ARRDC3 regulates ...
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes 2010; 59: 1424-1434.Chutkow WA, Birkenfeld AL, Brown JD, et al. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adi- po...
Regulation of ALIX ubiquitination and function in GPCR lysosomal sorting by the alpha‐arrestin ARRDC3 (604.3)We recently discovered that protease-activated receptor-1 (PAR1), a GPCR for thrombin, is sorted to lysosomes through an ALIX-mediated pathway in...
an alpha- Arrestin Scaffold Proteinin Endothelial Signaling UNIVERSITY OF ROCHESTER Bradford C. Berk SpindelOded NCardiovascular diseases (CVD) are among the leading causes for morbidity and mortality in the western world. Examples of CVD include congestive heart failure, coronary artery disease and ...