Alpha-synuclein aggregation and mitochondrial defects are believed to be central in the pathogenesis of neurodegeneration in PD [3, 10, 45, 46]. This is clearly reinforced by the fact that mutations of α-syn or mitochondria-associated genes can cause the onset of familial early-onset ...
Background The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the...
Alpha-synuclein (SNCA) is crucial in the pathogenesis of Parkinson's disease (PD), yet mutations in the SNCA gene are rare. Evidence for somatic genetic variation in normal humans, also involving the brain, is increasing, but its role in disease is unknown. Somatic SNCA mutations, arising in...
Peripheral alpha‐synuclein and Parkinson's disease 来自 EBSCO 喜欢 0 阅读量: 63 作者:CW Olanow,DR Wakeman,JH Kordower 摘要: First page of article 关键词: Parkinson's disease DOI: 10.1002/mds.25966 被引量: 25 年份: 2014 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 ...