Dosage forms: oral capsule (100 mg; 25 mg; 50 mg), oral suspension (100 mg/5 mL) Drug class: Carbonic anhydrase inhibitor anticonvulsantsMedically reviewed by Drugs.com on Jul 3, 2023. Written by Cerner Multum.Uses Side effects Warnings Before taking Dosage Interactions What...
Capsules: 25 mg, 50 mg, 100 mg Indications and dosages ➣ Adjunctive treatment of partial seizures Adults and children older than age 16: Initially, 100 mg P.O. daily for 2 weeks, then, if required, increased to 200 mg P.O. daily for at least 2 weeks. May increase in 100-mg in...
Zonisamide Dosage and Form Information Supplied As Strength Capsule 50 Mg 25 Mg 100 Mg
25 mg bd for 7 days, 50 mg bd for 7 days, then increased by 100 mg every 7 days; usual maintenance 300– 500 mg daily, divided into 1 or 2 doses (dose to be increased every 14 days in patients who are not on carbamazepine, phenobarbital, phenytoin, or other potent inducers of cy...
Adverse effects occur more frequently at dosages ≥300 mg daily.Special PopulationsHepatic ImpairmentTitrate dosage slowly.Renal ImpairmentTitrate dosage slowly. Do not use in patients with renal failure (GFR <50 mL/minute).Geriatric Patients
In the UK, the usual initial oral dose in adults over 18 years of age is 50 mg daily in 2 divided doses, in- creased after 1 week to 100 mg daily. Thereafter, the dose may be further increased at weekly intervals by increments of up to 100 mg, to a usual dose of 300 to 500 ...
Side effectsAbstarct Zonisamide (Zonegran, Excegran) is a new-generation, broad-spectrum antiepileptic drug (AED) currently approved as adjunctive therapy for the treatment of medically refractory partial seizures in adults in the US and as adjunctive therapy or monotherapy in the control of partial ...
Urinalysis has revealed that zonisamide undergoes biotransformation by acetylation and also cleavage of the isoxazole ring followed by conjugation with glucuronic acid. In Japan, the parent drug and glucuronide conjugate have accounted for almost 50% of a 200mg dose recovered in the urine of volunteers...
Objective: To evaluate the efficacy, safety and tolerability of daily doses of 25, 50, and 100 mg of zonisamide (ZNS) administered as adjunctive treatment... M Murata,K Hasegawa,I Kanazawa - 《Neurology》 被引量: 201发表: 2007年 Carbonic anhydrase inhibitors. Zonisamide is an effective inhib...
12. The method according to claim 10, wherein said effective amount of zonisamide is in the range of about 50 to about 1000 mg/day. 13. The method according to claim 12, wherein said effective amount of zonisamide is in the range of about 100 to about 600 mg/day. ...