建立小鼠肿瘤异种移植模型以证实ZEB2-AS1对体内肿瘤生长的影响。 结果显示,在AML组织和细胞中,ZEB2-AS1和PLK1的表达水平上调,而miR-122-5p的表达水平下调。ZEB2-AS1的组合在体外抑制增殖并诱导凋亡,并在体内抑制肿瘤生长。通过实验验证,发现ZEB2-AS1负调控miR-122-5p的表达,而PLK1被视为miR-122-5p的靶基因。此外,...
越来越多的研究发现长非编码RNA(long non-coding RNA,LncRNA)通过调节与细胞增殖和凋亡相关的基因来影响肿瘤的发生与发展.LncRNA ZEB2-AS1在体内和体外通过多种方式调节肿瘤细胞生物学行为,包括增殖,迁移,侵袭,凋亡和糖酵解.本文对ZEB2-AS1对肿瘤生物学行为的影响及作用机制研究进展进行综述,以评价ZEB2-AS1作为肿瘤...
[目的]1.应用基因芯片技术筛选急性髓系白血病(AML)患者差异表达的长链非编码RNA.2.应用实时定量PCR分析在AML患者骨髓单个核细胞中长链非编码RNA ZEB2-AS1的表达特征,并分析其与临床预后及复发的相关性.3.研究长链非编码RNA ZEB2-AS1对人AML白血病细胞株(THP-1,NB4细胞)生物学功能的影响,并探讨其可能的机制.[方法...
锌指E盒结合同源盒蛋白2-AS1(ZEB2-AS1)目的通过表达谱芯片筛选卵巢癌(OC)有价值的核心长链非编码RNAs(lncRNAs)分子,并进行表达验证和分析.方法收集宁夏医科大学总医院2018年1月至2019年6月OC组织36份,正常卵巢组织22份,以表达谱芯片检测差异表达lncRNAs和mRNAs分子,以real-time PCR验证lncRNAs表达,原位杂交验证关键...
However, the role of lncRNA zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in CRC remains largely unknown.Methods: The authors detected the ZEB2-AS1 expression in CRC tissue sample and CRC cell lines. The effects of ZEB2-AS1 on CRC were identified through in vitro assays...
However, the role of lncRNA zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1) in CRC remains largely unknown.Trends in Ecology & Evolution
Enforced overexpression of ZEB2 largely attenuated the phenotypic changes resulted from ZEB2‐AS1 inhibition except the impaired cell proliferation. In addition, ZEB2‐AS1 was required for TGF‐β1‐induced epithelial‐mesenchymal transition (EMT) in vitro. Significantly reduced tumour growth and lung ...
Enforced overexpression of ZEB2 largely attenuated the phenotypic changes resulted from ZEB2-AS1 inhibition except the impaired cell proliferation. In addition, ZEB2-AS1 was required for TGF-尾1-induced epithelial-mesenchymal transition (EMT) in vitro. Significantly reduced tumour growth and lung ...
Page for ZEB2-AS1-1
ZEB2-AS1ExpressionPrognosisLung CancerNSCLCObjective: ZEB2-AS1 has been suggested as an oncogene in some types of cancers, and it was also found to be up-regulated in NSCLC tissues compared with corresponding normal lung tissues. However, study on the clinical significance and prognosti...