Hemiplegic migraine (HM) is a rare disease with an estimated prevalence of 0.01% in the general population [6,7]. Familial HM, diagnosed when at least one first- or second-degree relative also has HM, accounts
Migraine is predominantly polygenic, with multiple genetic variants, each with a minor-effect size, accumulating to lead to the disease. A portion of MwA cases could be explained by the conjunction of a small number of genetic variants with moderate effect size, or by a single variant with a ...