For example, utilizing NGS and other technologies, The Cancer Genome Atlas (TCGA) has cataloged the prevalent genomic aberrations in multiple malignancies (1). NGS continues to be utilized for basic biologic discovery in cancer laboratories across the world and has led to additional discoveries not...
From the molecular standpoint, tumor groups are associated with differentiation, invasive properties, and particularly with cancer architecture—papillary versus follicular. The recognition of RAS-like and BRAF V600E-like molecular profiles—formalized by the work by the The Cancer Genome Atlas (TCGA) ...
Cancer is associated with the interaction of thousands of gene products, and genotype as well as interactions vary greatly within and between tumors [87], which is a key reason for the failure of some drugs. In contrast to bulk analysis, which does not account for the differences between ...
At a more complex level, it includes patient-derived test systems, such as patient-derived xenograft (PDX) models in cancer 51, 64. These types of system might have a significant impact on drug discovery in the future; however, at the current stage, there is relatively little data available...
Groups such as Biomedical Informatics Research Network (BIRN), the Stroke Imaging Research Consortium (STIR), the Cancer Genome Atlas (TCGA), ADNI 18 and Autism Brain Imaging Data Exchange (ABIDE) 19 have produced the infrastructure to help groups share data. The development of common data ...
Using our own and TCGA data we then evaluated five possible models to explain the selection for non-random accumulation of LOH in ovarian cancer genomes: 1. Classic two-hit hypothesis: high frequency biallelic genetic inactivation of tumour suppressor genes. 2. Epigenetic two-hit hypothesis: ...
Cancer Genome Atlas Liver Hepatocellular Carcinoma TCGA-LIHC Caudal Type Homeobox 2 CDX2 CCCTC-binding factor CTCF clonal hematopoiesis CH colorectal tumors CRC C-X-C motif chemokine ligand 14, Diffuse Intrinsic Pontine Gliomas DIPGs 16,16-dimethyl-PGE2 dmPGE2 DNA damage repair DDR DNA-dependent pr...
Scientists have found that some of the mechanisms of action of drugs suitable for MSI-H treatment, such as PD-L1 (programed cell death ligand 1) immunosuppressant, can produce heteroantigens that are easy to be recognized by T cells in dMMR cancer cells, which is beneficial to a variety ...
(ExAC) database that were not contributed via The Cancer Genome Atlas (TCGA; non-TCGA ExAC), assuming lifetime penetrance for MTC of 90%, 50%, and unbounded.#Population-based.#Ten of 61 ATA disease-causing RET mutations were present in the non-TCGA ExAC population with observed frequency ...
Accessing the massive amount of breast cancer data that are currently publicly available may seem daunting to the brand new graduate student embarking on his/her first project or even to the seasoned lab leader, who may wish to explore a new avenue of in