What causes early-onset Alzheimer’s? While the exact causes of early Alzheimer’s disease aren’t fully understood yet, scientists believe it’s caused by the abnormal build-up of two proteins in the brain known as amyloid and tau. At a basic level, the failure of these proteins to funct...
Alzheimer's disease, Tau, Inflammation, Glia, Astrocytes, MicrogliaAlzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60鈥 80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia. AD is characterized by ...
amyloid and tau are the two dysfunctional proteins, and they can be measured in a patient's spinal fluid. The form of abnormal tau that can be involved in FTD is different than in Alzheimer's disease, which adds to the complexity of diagnosis when using...
In the last 20 years it has been widely demonstrated that cell nucleus contains neutral and polar lipids localized in nuclear membranes, nucleoli, nuclear matrix and chromatin. Nuclear lipids may show specific organization forming nuclear lipid microdomains and have both structural and functional roles....
Background:The NIA-AA research framework proposes a biological definition of Alzheimer's disease,where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.Discussion:Notwithstanding the fact that amyloid deposition in isolation is not associated with ...
may be drivers of disease. In Alzheimer's disease, amyloid and tau are the two dysfunctional proteins, and they can be measured in a patient's spinal fluid. The form of abnormal tau that can be involved in FTD is different than in Alzheimer's disease, which adds to the complexity of di...
The study of protein aggregation, and amyloidosis in particular, has gained considerable interest in recent times. Several neurodegenerative diseases, such as Alzheimer’s (AD) and Parkinson’s (PD) show a characteristic buildup of proteinaceous aggregates in several organs, especially the brain. Des...