Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia. It most often emerges during a person’s mid-60s or older, although early-onset varieties exist. Its exact cause remains unclear. Alzheimer’s and other dementias Dementia describes a group of ...
Background:The NIA-AA research framework proposes a biological definition of Alzheimer's disease,where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.Discussion:Notwithstanding the fact that amyloid deposition in isolation is not associated with ...
Viral S protein accumulates in the host cell endoplasmic reticulum (ER) and directly modulates the host unfolded protein response (UPR) to promote viral replication [13]. After entering the host cell, the COVID-19 virus genome is then released inside the host cell and the virus replicates its...
Alzheimer’s disease, the most common neurodegenerative condition, is reaching epidemic proportions. In the absence of effective interventions, over 50 million people worldwide will suffer from this devastating dementia by the year 2050 [2]. The symptoms of AD begin insidiously with memory impairment ...
physiopathology of numerous cell types. In neural cells the nuclear lipids are involved in cell proliferation, differentiation, inflammation, migration and apoptosis. Abnormal metabolism of nuclear lipids might be closely associated with tumorigenesis and neurodegenerative diseases such as Alzheimer disease ...
Neu- rological manifestations and BBB disruption mechanism(s) are the major complications in long-COVID-19 [19]. The proposed interaction of COVID-19, after entry, within the nervous system tissues, is sketched (Fig. 2). Neuro‑inflammation Neuro-inflammation is one of the major ...