Some in the biopharmaceutical industry have noted that very few new technologies were created and applied to address the COVID-19 pandemic because there was no time to perform critical development activities. While this is perhaps unsurprising in a public health emergency,...
NRAMP1 is a critical mediator in the innate immune response to tuberculosis infection which leads to decreased DNA replication and respiratory chain function in M. tuberculosis [16], but the precise function of this protein remains unclear [6]. Several polymorphisms have been described in the ...
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Guidelines by the International Conference on Harmonization (ICH), ICH Q7 and ICH Qll, and further guidance by regulatory authorities, such as the US Food and Drug Administration and the European Medicines Agency, provide direction, but the definition of starting materials is specific to a given ...