In the last 20 years it has been widely demonstrated that cell nucleus contains neutral and polar lipids localized in nuclear membranes, nucleoli, nuclear matrix and chromatin. Nuclear lipids may show specific organization forming nuclear lipid microdomains and have both structural and functional roles....
This unique potential is advantageous for human mitochondrial disease modelling. Figure 1. Generation and utility of human stem cell models. Human pluripotent stem cells (hPSCs) can be generated either from the inner cell mass of a blastocyst, known as human embryonic stem cells (hESCs), or by...
amyloids; amyloid precursor protein; amyloid structure analysis; protein aggregation; fibril formation; Aβ peptide; amyloid related diseases; physical techniques in amyloid analysis; COVID-19 and amyloidosis 1. Introduction It is impressive how nature accurately implements molecular self-assembly through ...
The transwell assay is another 2D model that can be used to study cell invasion [112]. This assay is based on the original Boyden assay system, consisting of two chambers separated by an insert with a porous membrane. Tumour cells are seeded in the upper chamber, while, in the lower one...