18F-FDG-PET response has been correlated with Akt inactivation and plasma membrane GLUT1 expression in a study with mTOR inhibitors (Ma et al, 2009). Measuring off-target effects on metabolism The effect of antiangiogenic agents on 18F-FDG uptake has been explored with reduction in SUVmax ...
A systematic review and meta-analysis showed high sensitivity and specificity estimates for malignant lymph node detection on FDG PET/CT by using either an absolute SUV threshold (SUVmax 2.5) or a relative one (lymph node versus background uptake) [18]. However, the semi-quantitative analysis ...
Continuously low insulin levels lead to increased uptake of FFAs into the mitochondria of liver cells via carnitine palmitoyltransferase (CPT-1). Once entering the mitochondria, fatty acids are broken down into acetyl-CoA via β-oxidation. During the classic KD, the liver oxidizes FFAs at high ...