Viral S protein accumulates in the host cell endoplasmic reticulum (ER) and directly modulates the host unfolded protein response (UPR) to promote viral replication [13]. After entering the host cell, the COVID-19 virus genome is then released inside the host cell and the virus replicates its...
In the last 20 years it has been widely demonstrated that cell nucleus contains neutral and polar lipids localized in nuclear membranes, nucleoli, nuclear matrix and chromatin. Nuclear lipids may show specific organization forming nuclear lipid microdomains and have both structural and functional roles....
It is known that type 2 diabetes causes damage to the brain and body relative to sugar and the insulin response. Mild cognitive dysfunction can also be a result of type 2 diabetes. Is this a path to Alzheimer's disease? Dr. Sam Gandy, M.D., Ph.D., said on the Alzheimer’s Associa...
Abbreviations Aβ: Amyloid beta; ACE2: Angiotensin-converting enzyme-2; AD: Alzheimer's disease; ANRIL: Antisense non-cod- ing RNA in the INK4 locus; ARDS: Acute respiratory distress syn- drome; ATG: Autophagy-related-genes; BBB: Blood–brain barrier; C5aR: ...