viruses, as obligate intracellular parasites, exploit host cellular mechanisms for their survival, complicating efforts to selectively target them adversely affecting host cells. The following sections provide a detailed overview of some antiviral drugs...
which has been associated with encouraging results. In a study in New Zealand and Australia, ECMO-treated patients with influenza A(H1N1)-associated ARDS were often young adults with severe hypoxemia and had an overall survival rate greater than 70% [28]. This ...
b Change in body weight, c Kaplan–Meier analysis of the survival rate, and d neurological scores of IVE mice; n = 5–11. e Plaque titration assay of the brains of IVE mice treated with BXA or PER. n = 4–9. f Expression of the IAV-NP gene and g quantification of IAV-NP in ...
Mosquito-borne viruses (MBVs) are a major global health threat, causing significant morbidity and mortality. MBVs belong to several distinct viral families, each with unique characteristics. The primary families includeFlaviviridae(e.g., Dengue, Zika, West Nile, Yellow Fever, Japanese Encephalitis),...
Analysis of the survival of Venezuelan equine encephalomyelitis virus and possible viral simulants in liquid suspensionsalphavirusbiodefensedisinfectionenvironmental waterSindbissimulantVenezuelan equine encephalitiswaterAims: To compare the inactivation rate of Venezuelan equine encephalomyelitis (VEE) virus in ...
Although infection of the central nervous system can occur after hematogenous spread, invasion via the peripheral nerves is also an important route of infection—for example, in rabies, Borna disease, and several alphaherpesvirus infections (e.g., B virus encephalitis, pseudorabies, and bovine herpes...
et al. Ebola virus disease complicated by late-onset encephalitis and polyarthritis, Sierra Leone. Emerg. Infect. Dis. 22, 150–152 (2016). Article CAS PubMed PubMed Central Google Scholar Jacobs, M. et al. Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet 388,...
heart but failed to detect the underlying cause. Metagenomic analysis of brain samples revealed Pseudomonas spp. and MDV both linked to chicken meningoencephalitis. This finding underscores the limitations of traditional diagnostic methods and demonstrates the power of metagenomics in identifying unexpected...
Mbithi, J.N., Springthorpe, S., Boulet, J.R., Sattar, S.A.: Survival of hepatitis A virus on human hands and its transfer on contact with animate and inanimate surfaces. J. Clin. Microbiol. 1992; 30: 757–763 PubMedCASGoogle Scholar ...
Peli1 was found to be a negative regulator of type I IFN expression within the CNS. Since type I IFN expression and signaling in the CNS are critical for host protection after viral encephalitis,45,46the authors proposed that Peli1-KO mice have better survival than WT mice. It has been...