We expect that most researchers who use ANOVA will do their analyses with a statistical computer application such as SAS or SPSS. For the various effects of interest, these programs provide estimates of the standard error. Recall that the fundamental formula for computing a confidence interval is ...
For the parameters estimation is commonly used ridge-stabilized Newton- Raphson algorithm, which is implemented in the GENMOD procedure (SAS, 2011). In the -th iteration, the algorithm updates the parameter vector as following: =− where is Hessian matrix, and is the gradient vector of the ...
Previous work has shown that naive two-stage, vQTL screening-based interaction testing procedures can have inflated type I error whenever the exposure tested in stage two is associated with the outcome, due to a correlation between test statistics for stage one and stage two23. In the context ...