Monitor patients for elevated serum creatinine prior to and periodically during treatment. Administer corticosteroids for Grades 2-4 increased serum creatinine. Withhold OPDIVO for Grade 2 or 3 and permanently discontinue for Grade 4 increased serum creatinine. In patients receiving OPDIVO monothe...
The serum miR-122 level was found to be significantly increased concomitantly to rejection signs, and then it decreased 6 months after the resolution of rejection, with a kinetic similar to those of AST and ALT [17]. The serum concentrations of miR-122 were significantly elevated in patients ...